methyl N6-[(1,1-dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysinate
- Cas number：2389-49-3
- purity：99%
Product Details
Cost-effective and customizable methyl N6-[(1,1-dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysinate 2389-49-3 factory
- Molecular Formula: C20H30 N2 O6
- Molecular Weight: 394.468
- Vapor Pressure: 6.34E-12mmHg at 25°C
- Melting Point: 62.5-63.5 °C
- Boiling Point: 544.7°Cat760mmHg
- PKA: 10.95±0.46(Predicted)
- Flash Point: 283.2°C
- PSA： 102.96000
- Density: 1.13g/cm3
- LogP: 3.93120
methyl N6-[(1,1-dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysinate(Cas 2389-49-3) Usage
InChI:InChI=1/C20H30N2O6/c1-20(2,3)28-18(24)21-13-9-8-12-16(17(23)26-4)22-19(25)27-14-15-10-6-5-7-11-15/h5-7,10-11,16H,8-9,12-14H2,1-4H3,(H,21,24)(H,22,25)
2389-49-3 Relevant articles
Serine- and threonine-derived diamine equivalents for site-specific incorporation of platinum centers in peptides, and the anticancer potential of these conjugates
Kumbhakonam, Sateeshkumar,Vellaisamy, Kasipandi,Saroj, Soumya,Venkatesan, Nalini,Karunagaran,Manheri, Muraleedharan Kannoth
, p. 2450 - 2458 (2018/02/19)
A modular strategy that allows introduct...
Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists
-
Paragraph 0323, (2014/09/03)
The present invention relates to a conju...
Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists
-
Paragraph 0412; 0432, (2014/09/03)
A conjugated compound of Formula I: Q-Z—...
Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids
-
Paragraph 0174; 0175, (2014/01/08)
The present invention concerns a conjuga...
2389-49-3 Process route
-
-
2389-60-8
Z-Lys(Boc)-OH
-
-
2389-49-3
Nα -(benzyloxycarbonyl)-Nε -(tert-butoxycarbonyl)-L-lysine methyl ester
| Conditions | Yield |
|---|---|
|
Z-Lys(Boc)-OH;
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
With
methyl iodide;
In
N,N-dimethyl-formamide;
at 20 ℃;
|
96%
|
|
Multi-step reaction
with
2
steps
1: oxalyl chloride / CH2
Cl2
; dimethylformamide / 1 h / 0 °C
2: CH2
Cl2
/ 1 h / Ambient temperature
With
oxalyl dichloride;
In
dichloromethane; N,N-dimethyl-formamide;
|
-
-
67-56-1
methanol
-
-
2389-60-8
Z-Lys(Boc)-OH
-
-
2389-49-3
Nα -(benzyloxycarbonyl)-Nε -(tert-butoxycarbonyl)-L-lysine methyl ester
| Conditions | Yield |
|---|---|
|
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
dichloromethane;
at 20 ℃;
for 2h;
pH=8;
|
99%
|
|
With
dmap; dicyclohexyl-carbodiimide;
Inert atmosphere;
|
94%
|
|
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
dichloromethane;
at 20 ℃;
for 2h;
pH=8;
|
2389-49-3 Upstream products
-
186581-53-3
diazomethane
-
2212-76-2
Nα -benzyloxycarbonyl-Nε -tert-butyloxycarbonyl-L-lysine dicyclohexylamine salt
-
67-56-1
methanol
-
1070-19-5
N-(tert-butyloxycarbonyl) azide
2389-49-3 Downstream products
-
3017-32-1
(S)-methyl 2-amino-6-(tert-butoxycarbonylamino)hexanoate
-
5591-93-5
(S)-methyl 6-amino-2-(benzyloxycarbonylamino)hexanoate
-
122314-13-0
tert-butyl-N-[(5S)-5-(benzyloxycarbonylamino)-6-oxo-hexyl]carbamate
-
26348-68-5
N-(benzyloxycarbonyl)lysine methyl ester hydrochloride
methyl N6-[(1,1-dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysinate
CAS:2389-49-3
Purity:99%
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