2-[[(4-methoxyphenyl)methylhydrazono]methyl]-1,3,3-trimethyl-3H-indolium thiocyanate

Type of compound

Voltage-dependent anion channel (VDAC) inhibitor

Function

Fluorescent mitochondrial probe

Uses in research

Studying mitochondrial function and dynamics, visualizing mitochondrial morphology and membrane potential

Potential therapeutic applications

Cancer therapy by inducing apoptosis in cancer cells

Characteristics

Potent, reversible inhibitor of VDAC

Additional notes

Promising compound with diverse potential applications in mitochondrial research and therapeutic development.

General Description

2-[[(4-methoxyphenyl)methylhydrazono]methyl]-1,3,3-trimethyl-3H-indolium thiocyanate, also known as MitoBloCK-6, is a chemical compound that has been used as a fluorescent mitochondrial probe. It is a member of the voltage-dependent anion channel (VDAC) inhibitors and has been shown to be a potent, reversible inhibitor of the VDAC. MitoBloCK-6 has been used in research to study mitochondrial function and dynamics and has been shown to be useful in visualizing mitochondrial morphology and membrane potential. It has also been investigated for its potential role in cancer therapy, as it has been found to induce apoptosis in cancer cells. MitoBloCK-6 is a promising compound with diverse potential applications in mitochondrial research and therapeutic development.